Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium, Published online: 24 September 2018; doi:10.1038/s41586-018-0558-4

Structures of the transient receptor potential melastatin 2 channel in the apo resting (closed) state and in the ADP-ribose/Ca2+-bound active (open) state are determined by cryo-electron microscopy.
Source: Nature