Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling, Published online: 29 August 2018; doi:10.1038/s41586-018-0462-y

Cotranslational assembly is a prevalent mechanism for the formation of oligomeric complexes in Saccharomyces cerevisiae, with one subunit serving as scaffold for the translation of partner subunits.
Source: Nature

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes, Published online: 28 March 2018; doi:10.1038/nature26158

Cryo-electron microscopy and biochemical analyses of the GATOR1 protein complex reveal that two binding modes underpin its ability to regulate Rag GTPases as a GTPase-activating protein for RAGA.
Source: Nature