Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate, Published online: 19 September 2018; doi:10.1038/s41586-018-0557-5

In the CRISPR type III system, ‘ring’ nucleases possess a metal-independent mechanism that cleaves cyclic oligoadenylate ring molecules to switch off the antiviral state in cells.
Source: Nature