ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase

ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase, Published online: 16 May 2018; doi:10.1038/s41586-018-0137-8

ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.
Source: Nature