Nobel-winning therapy weaponises immune system against cancer

Nobel-winning therapy weaponises immune system against cancerJames Allison of the US and Tasuku Honjo of Japan won the Nobel on Monday for identifying two different brakes on the immune system which, when turned off, allow the body’s defence system to attack cancerous cells faster and more effectively. Allison was one of two scientists to discover the blocking effect for one such brake — or checkpoint inhibitor molecule — called CTLA-4 in 1995.


Source: Yahoo! News

Doctors issue caution over missed cancer diagnoses tied to immune disorder

Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. They caution that expediting HLH treatment may miss underlying malignancies that could end up being fatal to the patient.
Source: Science Daily

How our immune system detects broken DNA

Our immune system can detect when our own cells are damaged. This DNA damage can come from a variety of sources, such as the sun’s UV rays, chemical agents like cigarette smoke, or from genotoxic drugs used in chemotherapy. A new study found that DNA damage can lead to an immune response similar to that observed during viral infection.
Source: Science Daily

HIV RNA expression inhibitors may restore immune function in HIV-infected individuals

Immune activation and inflammation persist in the majority of treated HIV-infected individuals and is associated with excess risk of mortality and morbidity. A new study suggests that use of HIV RNA expression inhibitors as adjunct therapy might diminish atypical inflammation and restore immune function in HIV-infected individuals on combination antiretroviral therapy (cART).
Source: Science Daily

Gut's 'taste buds' help school the immune system in the thymus

Researchers were recently surprised to discover fully formed gut and skin cells in the thymus, a lemon-sized organ that sits in front of the heart and is responsible for training the T cells of the immune system not to attack the body’s own tissues. The finding, based on studies conducted in mice, could lead to better understanding of the drivers of autoimmune problems in humans, the authors say.
Source: Science Daily

Immune discovery should help develop improved vaccines for infants and newborns

Specific immune danger signals are highly efficient in triggering immune responses in infants and newborns, whose immune systems function very differently to those of adults. The scientists believe their discovery could reduce both the age at which vaccines can be first administered, and the need for multiple booster shots.
Source: Science Daily

Immune discovery should help develop improved vaccines for infants and newborns

Specific immune danger signals are highly efficient in triggering immune responses in infants and newborns, whose immune systems function very differently to those of adults. The scientists believe their discovery could reduce both the age at which vaccines can be first administered, and the need for multiple booster shots.
Source: Science Daily

Resistance to prostate-cancer treatment is driven by immune cells

Resistance to prostate-cancer treatment is driven by immune cells

Resistance to prostate-cancer treatment is driven by immune cells, Published online: 27 June 2018; doi:10.1038/d41586-018-05460-y

Prostate-cancer treatment usually fails after time as resistance to therapy develops. It emerges from studies of mice and human cells that a population of immune cells can cause this type of treatment resistance.
Source: Nature