Scientists ID source of damaging inflammation after heart attack

Scientists have zeroed in on a culprit that spurs damaging inflammation in the heart following a heart attack. The guilty party is a type of immune cell that tries to heal the injured heart but instead triggers inflammation that leads to even more damage. The researchers also have found that an already approved drug effectively tamps down such inflammation in mice, protecting the heart from the progressive damage that often occurs after a heart attack.
Source: Science Daily

Chemical compound produces beneficial inflammation, remyelination that could help treat multiple sclerosis

Researchers report that indazole chloride, a synthetic compound that acts on one form of the body’s estrogen receptors, is able to remyelinate (add new myelin to) damaged axons and alter the body’s immune system — findings that could help treat multiple sclerosis. Drugs available to treat MS alter the immune system but do not induce repair of damaged axons.
Source: Science Daily

Bystander T cells can steal the show in resolving inflammation

New research reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. The finding is noteworthy because that chief anti-inflammatory role has been traditionally ascribed to what are called regulatory T cells, or ‘Tregs,’ which dampen autoimmune responses. The new study challenges this notion and suggests alternate mechanisms can also be at work.
Source: Science Daily