Xiaomi Mi MIX 3 Announced With 10GB Of RAM & Sliding Camera Mechanism

  1. Xiaomi Mi MIX 3 Announced With 10GB Of RAM & Sliding Camera Mechanism  Android Headlines
  2. Xiaomi’s Mi Mix 3 is an all-screen magnetic slider phone with 10GB of RAM  Ars Technica
  3. New Android flagship from China has a whopping 10GB of RAM  BGR
  4. Xiaomi’s all-screen Mi Mix 3 slider comes with up to 10GB RAM  Engadget
  5. Full coverage


Source: Google News -Technology

Unveiling the mechanism protecting replicated DNA from degradation

Researchers have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. Consequently, they were able to gain unprecedented access to the mechanism behind how AND-1 works during DNA replication and cell proliferation in vertebrate cells, demonstrating that AND-1 has two different functions during DNA replication mediated by different domains of AND-1.
Source: Science Daily

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium, Published online: 24 September 2018; doi:10.1038/s41586-018-0558-4

Structures of the transient receptor potential melastatin 2 channel in the apo resting (closed) state and in the ADP-ribose/Ca2+-bound active (open) state are determined by cryo-electron microscopy.
Source: Nature

Author Correction: Structure and mechanogating mechanism of the Piezo1 channel

Author Correction: Structure and mechanogating mechanism of the Piezo1 channel

Author Correction: Structure and mechanogating mechanism of the Piezo1 channel, Published online: 10 September 2018; doi:10.1038/s41586-018-0513-4

Author Correction: Structure and mechanogating mechanism of the Piezo1 channel
Source: Nature

Mechanism of Marburg virus sexual transmission identified in nonhuman primates

New research elucidates the mechanism of sexual transmission of filoviruses, which have been shown to persist in the testes and other immune privileged sites. Sexual transmission of filoviruses was first reported in 1968 after an outbreak of Marburg virus disease and recently caused flare-ups of Ebola virus disease in the 2013-2016 outbreak. The team found that Marburg virus persists in seminiferous tubules and that Sertoli cells are the reservoir for the virus.
Source: Science Daily

Malaria parasite translocon structure and mechanism of effector export

Malaria parasite translocon structure and mechanism of effector export

Malaria parasite translocon structure and mechanism of effector export, Published online: 27 August 2018; doi:10.1038/s41586-018-0469-4

Cryo-electron microscopy analysis of the purified Plasmodium translocon of exported proteins (PTEX) reveals two distinct resolved states, suggesting a mechanism by which Plasmodium falciparum exports malarial effector proteins into erythrocytes.
Source: Nature

A chaperonin protein, GroEL, has a more complex mechanism than was thought before

Scientists have studied molecular interactions in the chaperonin protein GroEL. GroEL is alternately bound and unbound by a co-chaperonin, GroES. Against expectations, the ‘football’ complex — where two GroES units cap the cylindrical GroEL at either end — was roughly as prevalent as the single-bound ‘bullet’ complex. This implies that negative allosteric interactions preventing double-binding of GroEL sometimes fail, and the double-bound complex plays an active role in protein folding.
Source: Science Daily

A chaperonin protein, GroEL, has a more complex mechanism than was thought before

Scientists have studied molecular interactions in the chaperonin protein GroEL. GroEL is alternately bound and unbound by a co-chaperonin, GroES. Against expectations, the ‘football’ complex — where two GroES units cap the cylindrical GroEL at either end — was roughly as prevalent as the single-bound ‘bullet’ complex. This implies that negative allosteric interactions preventing double-binding of GroEL sometimes fail, and the double-bound complex plays an active role in protein folding.
Source: Science Daily

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13, Published online: 04 July 2018; doi:10.1038/s41586-018-0281-1

Structural analysis demonstrates how TRIP13 and p31comet disassemble the mitotic checkpoint complex.
Source: Nature